Translational Cardiovascular Biology
Our Research
Based in the Department of Medicine, I have spent time working in the field of vascular biology/stem cell biology in Stanford University. I am currently working on a number of exciting research projects as follows:
One project entitled 'Genetic Determinants of Peripheral Arterial Disease' explores the relationship between inflammation, endothelial dysfunction and adiposity in patients with coronary artery disease
I am also researching a project entitled 'L-arginine in Peripheral Arterial Disease: The No-Pain Study' which explores the role of l-arginine therapy in patients with peripheral arterial disease and examines the determinants of hemodynamic features and prognosis in patients with peripheral arterial disease focused on endothelial function assessment.
Another project entitled 'Biomarkers of Advanced Atherosclerosis (Gene-Pad Substudy)' looks at developing novel biomarkers for advanced atherosclerosis using high throughput proteomic techniques including SELDI-TOF mass spectrometry
Our staff and students
Our collaborators
- Professor John Cooke, Falk Cardiovascular Research Institute, Stanford University
- Dr Andrew Boyle, UCSF Medical Center
- Assoc Professor Clive May, Howard Florey Research Institute
Our major grants
- NHMRC Neil Hamilton Fairley Fellowship
- RACP Bayer Overseas Fellowship
- St Vincent's Research Fund
- Australian Lupus Research Fund
Our key publications
- Wilson AM, et al. Beta 2 Microglobulin as a Biomarker in Peripheral Arterial Disease: Proteomic Profiling and Clinical Studies. Circulation 2007 Sep 18;116(12):1396-403. Epub 2007 Aug 27
- Wilson AM, et al. L-Arginine supplementation in Peripheral Arterial Disease: No benefit and possible harm. Circulation 2007 Jul 10;116(2):188-95. Epub 2007 Jun 25
- Wilson AM, et al. A Biomarker Panel for Peripheral Arterial Disease. Vascular Med (In press, 2008)
- Wilson AM, et al. Widespread vascular production of C-reactive protein (CRP) and a relationship between serum CRP, plaque CRP and intimal hypertrophy. Atherosclerosis 2007 Mar;191 (1):175-81
- Wilson AM. Are Vascular Function Measurements Ready for the Clinic? European Heart J. 2006 Feb; 27(3):255-7
- Wilson AM, et al. Comparison of Arterial Assessments in Low and High Vascular Disease Risk Groups. Am J Hypertens. 2004 Apr; 17(4): 285-91
Further information
Contact - enquiries @ medstv.unimelb.edu.au