Dr Andrzej Januszewski
Research Fellow
| telephone | +61 3 9288 2664 |
| facsmilie | +61 3 9288 2581 |
| janand@medstv.unimelb.edu.au |
Profile
Dr Andrzej Januszewski is a Research Fellow interested in the role of oxidation and advanced glycation end products (AGEs) in development and progression of diabetes complications. Primary field of expertise is in gas chromatography and mass spectrometry using chemical and electron ionisation with various dervatisation techniques. Usage of HPLC, spectrophotometry and spectrofluorometry techniques in quantification of proteins/peptides and fluorophores. Statistical analysis of data and presentation.
University of Melbourne find an expert profile
Professional Activities:
Member of the societies:
Australian Atherosclerosis Society,
Australian Diabetes Society
International Maillard Reaction Society,
Polish Academy of Family Medicine,
Polish College of Family Physicians
Current Collaboration:
- Prof. Kevin Croft, University of Western Australia, School of Medicine and Pharmacology Royal Perth Hospital Unit: Measurements of plasma isoprostanes and other lipid-derived modification of plasma proteins in diabetes.
- Prof. Anthony Keech, University of Sydney, NHMRC Clinical Trials Centre: Measurements of the effects of fenofibrate on inflammation and oxidative stress markers (FIELD study).
- Prof. Kerry-Anne Rye, The Heart Research Institute, Camperdown NSW: Measurement of cell adhesion molecules inhibition by native and recombinant HDL in cell cultures.
- Prof. Geoff Howlett, University of Melbourne, Bio21 Institute: Measurement of thioflavin T fluorescence in plasma of patients with autoimmune diseases.
- Dr Merlin Thomas, Baker Heart Research Institute: Measurements of low molecular-weight fluorophores in plasma
Qualifications
MD PhD
Major Grants
- Good cholesterol and vascular abnormalities in diabetes and heart disease (NHMRC Project Grant 2007)
- 1,5-Anhydroglucitol and Glucose Variability in insulin treated diabetes (Australian Diabetes Society 2007)
- Mitochondrial oxidative stress and diabetic complications (Juvenile Diabetes Research Foundation Innovative Grant 2008)
Selected Publications
- AJ Jenkins, AS Januszewski, J McBride, CS Karschimkus, CL Nelson, TJ Lyons, DN O'Neal, J-X Ma, "Increased serum kallistatin levels in patients with Type 1 Diabetes and its vascular complications' Diabetes 2009, 58(suppl. 1), 804-P
- AS Januszewski, K-A Rye, C Karschimkus, AJ Jenkins, "Glycation of HDL reduces its anti-inflammatory properties" Diabetes 2009, 58(suppl. 1), 927-P
- ZS Valaydon, P Lee, GL Dale, AS Januszewski, KG Rowley, H Nandurkar, JD Best, TJ Lyons, AJ Jenkins, "Increased coated-platelet levels in end stage renal disease patients" Nephrology (Carlton) 2009, 14(2), 148-54
- AS Januszewski, M Thomas, CS Karschimkus, SJ Chung, KG Rowley, CL Nelson, D O'Neal, G Dragicevic, CA Harper, JD Best, AJ Jenkins., "Longitudinal analysis of low-molecular weight fluorophores in Type 1 Diabetes mellitus" Journal of Medical Investigations 2008, 55(1-2), 29-36
- Jenkins A, Zhang SX, Rowley K, Karschimkus C, Nelson CL, Chung JS, O'Neal D, Januszewski A, Croft KD, Mori TA, Dragicevic G, Harper C, Best J, Lyons TJ & Ma J-X. "Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes" Diabetic Medicine 2007, 24 (12): 1345-51.
- Nobecourt E, Davies MJ, Brown BE, Curtiss LK, Bonnet DJ, Charlton F, Januszewski A, Jenkins A, Barter PJ & Rye K. "The impact of glycation on apolipoprotein A-I structure and its ability to activate lecithin:cholesterol acyltransferase" Diabetologia 2007, 50(3): 643-53.
- AS Januszewski, SQ Chan, A Wilson, M Yii, KG Rowley, JD Best, AJ Jenkins, "Effects of glucose and in vitro synthesized AGEs on vascular outgrowth in adult human angiogenesis" Diabetes 2007, 56(Suppl. 1), A182
- N Sachithanandan, AS Januszewski, C Karschimkus, D O'Neal, N Alkatib, J Best, K Rowley, AJ Jenkins, "Increased Tissue Fluorescence in Type 1 Diabetes Complications and Inverse Relationships with Vascular Elasticity" Diabetes 2007, 56(Suppl. 1), A174
- Januszewski AS, Alderson N, Jenkins A, Thorpe SR & Baynes JW. "Chemical modification of proteins during peroxidation of phospholipids" J Lipid Res. 2005, 46: 1440-1449.